79 research outputs found

    Economic optimization of component sizing for residential battery storage systems

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    Battery energy storage systems (BESS) coupled with rooftop-mounted residential photovoltaic (PV) generation, designated as PV-BESS, draw increasing attention and market penetration as more and more such systems become available. The manifold BESS deployed to date rely on a variety of different battery technologies, show a great variation of battery size, and power electronics dimensioning. However, given today's high investment costs of BESS, a well-matched design and adequate sizing of the storage systems are prerequisites to allow profitability for the end-user. The economic viability of a PV-BESS depends also on the battery operation, storage technology, and aging of the system. In this paper, a general method for comprehensive PV-BESS techno-economic analysis and optimization is presented and applied to the state-of-art PV-BESS to determine its optimal parameters. Using a linear optimization method, a cost-optimal sizing of the battery and power electronics is derived based on solar energy availability and local demand. At the same time, the power flow optimization reveals the best storage operation patterns considering a trade-off between energy purchase, feed-in remuneration, and battery aging. Using up to date technology-specific aging information and the investment cost of battery and inverter systems, three mature battery chemistries are compared; a lead-acid (PbA) system and two lithium-ion systems, one with lithium-iron-phosphate (LFP) and another with lithium-nickel-manganese-cobalt (NMC) cathode. The results show that different storage technology and component sizing provide the best economic performances, depending on the scenario of load demand and PV generation.Web of Science107art. no. 83

    Hyperelliptic continued fractions and generalized jacobians: Minicourse given by Umberto Zannier

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    These are notes from the minicourse given by Umberto Zannier (Scuola Normale Superiore di Pisa). The notes were worked out by Laura Capuano, Peter Jossen,1 Christina Karolus, and Francesco Veneziano. Most of the material of these lectures, except for the numerical examples which were added by us, is already available in [45], The authors wish to thank Umberto Zannier for the lively discussions in Alpbach, and Olaf Merkert for providing computations of the examples 3.17, 3.28, 3.29, 3.33, and 3.25

    Mass Production of Mesenchymal Stem Cells — Impact of Bioreactor Design and Flow Conditions on Proliferation and Differentiation

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    The book serves as a good starting point for anyone interested in the application of tissue engineering. It offers a colorful mix of topics, which explain the obstacles and possible solutions for TE applications. The first part covers the use of adult stem cells and their applications. The following chapters offer an insight into the development of a tailored biomaterial for organ replacement and highlight the importance of cell-biomaterial interaction. In summary, this book offers insights into a wide variety of cells, biomaterials, interfaces and applications of the next generation biotechnology, which is tissue engineering

    Power input measurements in stirred bioreactors at laboratory scale

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    The power input in stirred bioreactors is an important scaling-up parameter and can be measured through the torque that acts on the impeller shaft during rotation. However, the experimental determination of the power input in small-scale vessels is still challenging due to relatively high friction losses inside typically used bushings, bearings and/or shaft seals and the accuracy of commercially available torque meters. Thus, only limited data for small-scale bioreactors, in particular single-use systems, is available in the literature, making comparisons among different single-use systems and their conventional counterparts difficult. This manuscript provides a protocol on how to measure power inputs in benchtop scale bioreactors over a wide range of turbulence conditions, which can be described by the dimensionless Reynolds number (Re). The aforementioned friction losses are effectively reduced by the use of an air bearing. The procedure on how to set up, conduct and evaluate a torque-based power input measurement, with special focus on cell culture typical agitation conditions with low to moderate turbulence (100 < Re < 2·104), is described in detail. The power input of several multi-use and single-use bioreactors is provided by the dimensionless power number (also called Newton number, P0), which is determined to be in the range of P0 ≈ 0.3 and P0 ≈ 4.5 for the maximum Reynolds numbers in the different bioreactors

    Integration of external and internal dosimetry in Switzerland

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    Individual monitoring regulations in Switzerland are based on the ICRP60 recommendations. The annual limit of 20 mSv for the effective dose applies to the sum of external and internal radiation. External radiation is monitored monthly or quarterly with TLD, DIS or CR-39 dosemeters by 10 approved external dosimetry services and reported as Hp(10) and Hp(0.07). Internal monitoring is done in two steps. At the workplace, simple screening measurements are done frequently in order to recognise a possible incorporation. If a nuclide dependent activity threshold is exceeded then one of the seven approved dosimetry services for internal radiation does an incorporation measurement to assess the committed effective dose E50. The dosimetry services report all the measured or assessed dose values to the employer and to the National Dose Registry. The employer records the annually accumulated dose values into the individual dose certificate of the occupationally exposed person, both the external dose Hp(10) and the internal dose E50 as well as the total effective dose E = Hp(10)+E50. Based on the national dose registry an annual report on the dosimetry in Switzerland is published which contains the statistics for the total effective dose, as well as separate statistics for external and internal exposur

    Using Semantic Web technologies in the development of data warehouses: A systematic mapping

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    The exploration and use of Semantic Web technologies have attracted considerable attention from researchers examining data warehouse (DW) development. However, the impact of this research and the maturity level of its results are still unclear. The objective of this study is to examine recently published research articles that take into account the use of Semantic Web technologies in the DW arena with the intention of summarizing their results, classifying their contributions to the field according to publication type, evaluating the maturity level of the results, and identifying future research challenges. Three main conclusions were derived from this study: (a) there is a major technological gap that inhibits the wide adoption of Semantic Web technologies in the business domain;(b) there is limited evidence that the results of the analyzed studies are applicable and transferable to industrial use; and (c) interest in researching the relationship between DWs and Semantic Web has decreased because new paradigms, such as linked open data, have attracted the interest of researchers.This study was supported by the Universidad de La Frontera, Chile, PROY. DI15-0020. Universidad de la Frontera, Chile, Grant Numbers: DI15-0020 and DI17-0043

    Diagenetic evolution of lower Jurassic platform carbonates flanking the Tazoult salt wall (Central High Atlas, Morocco)

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    Platform carbonates diagenesis in salt basins could be complex due to potential alterations of fluids related and non‐related to diapirism. This paper presents the diagenetic history of the Hettangian to Pliensbachian platform carbonates from the Tazoult salt wall area (central High Atlas, Morocco). Low structural relief and outcrop conditions allowed to define the entire diagenetic evolution occurred in the High Atlas diapiric basins since early stages of the diapiric activity up to their tectonic inversion. Precipitation of dolomite and calcite from both warmed marine‐derived and meteoric fluids characterised diagenetic stages during Pliensbachian, when the carbonate platforms were exposed and karstified. Burial diagenesis occurred from Toarcian to Middle Jurassic, due to changes of salt‐induced dynamic related to increase in siliciclastic input, fast diapir rise and rapid burial of Pliensbachian platforms. During this stage, the diapir acted as a physical barrier for fluid circulation between the core and the flanking sediments. In the carbonates and breccias flanking the structures, dolomite and calcite precipitated from basinal brines, whereas carbonate slivers located in the core of the structure, were affected by the circulation of Mn‐rich fluids. The final diagenetic event is characterised by the income of meteoric fluids into the system during uplift caused by Alpine orogeny. These results highlight the relevant influence of diapirism on the diagenetic modifications in salt‐related basins in terms of diagenetic events and involved fluids

    Numerical methods for the design and description of in vitro expansion processes of human mesenchymal stem cells

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    Human mesenchymal stem cells (hMSCs) are a valuable source of cells for clinical applications (e.g., treatment of acute myocardial infarction or inflammatory diseases), especially in the field of regenerative medicine. However, for autologous (patient-specific) and allogeneic (off-the-shelf) hMSC-based therapies, in vitro expansion is necessary prior to the clinical application in order to achieve the required cell numbers. Safe, reproducible, and economic in vitro expansion of hMSCs for autologous and allogeneic therapies can be problematic because the cell material is restricted and the cells are sensitive to environmental changes. It is beneficial to collect detailed information on the hydrodynamic conditions and cell growth behavior in a bioreactor system, in order to develop a so called “Digital Twin” of the cultivation system and expansion process. Numerical methods, such as Computational Fluid Dynamics (CFD) which has become widely used in the biotech industry for studying local characteristics within bioreactors or kinetic growth modelling, provide possible solutions for such tasks. In this review, we will present the current state-of-the-art for the in vitro expansion of hMSCs. Different numerical tools, including numerical fluid flow simulations and cell growth modelling approaches for hMSCs, will be presented. In addition, a case study demonstrating the applicability of CFD and kinetic growth modelling for the development of an microcarrier-based hMSC process will be shown

    Novel probes for pH and dissolved oxygen measurements in cultivations from millilitre to benchtop scale

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    Erworben im Rahmen der Schweizer Nationallizenzen (http://www.nationallizenzen.ch)pH value and the concentration of dissolved oxygen (DO) are key parameters to monitor and control cell growth in cultivation studies. Reliable, robust and accurate methods to measure these parameters in cultivation systems in real time guarantee high product yield and quality. This mini-review summarises the current state of the art of pH and DO sensors that are applied to bioprocesses from millilitre to benchtop scale by means of a short introduction on measuring principles and selected applications. Special emphasis is placed on single-use bioreactors, which have been increasingly employed in bioprocess development and production in recent years. Working principles, applications and the particular requirements of sensors in these cultivation systems are given. In such processes, optical sensors for pH and DO are often preferred to electrochemical probes, as they allow semi-invasive measurements and can be miniaturised to micrometre scale or lower. In addition, selected measuring principles of novel sensing technologies for pH and DO are discussed. These include solid-state sensors and miniaturised devices that are not yet commercially available, but show promising characteristics for possible use in bioprocesses in the near future

    Mental Toughness Attributes of Junior Level Medalist Badminton Players

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    The study aims to compare the mental toughness attributes between medalist and non-medalist badminton players and between male and female players. Participants were 15 male and 15 female badminton players aged between 13-19 years (M= 15.71, SD=2.82). Mental toughness questionnaire of Tiwari and Sharma was administered and the data were analyzed by using descriptive statistics and t-test. Medalist players have exhibited higher mean values on self-confidence, attention control, motivation and goal setting attributes. Overall mental toughness of medalists was higher 180.80±17.15 than non-medalists 170.25±20.10. Comparison analysis showed significant difference between medalists and non-medalists on mental toughness attributes: Self-confidence (SCO: p=0.001<0.05), medalists scored (M±SD=31.33±2.10) higher than non-medalists; motivation (MOT: p=0.006<0.05), medalist scored higher (M±SD=33.50±4.07; goal setting (GSE: p=0.044<0.05), medalists scored significantly higher (M±SD=33.55±4.11) than non-medalists. Other attributes did not show any significant difference between medalist and non-medalist players. When compared with gender, no significant difference was observed on mental toughness attributes except attention control (ATNCON: p=0.044<0.05), female players scored (M±SD=38.97±3.08) higher than male players. The findings confirm that mental toughness is a desired attribute which differentiates a medalist and non-medalist player. Connaughton et al., (2007) stated that elite competitive athletes possess better mental toughness. Medalist players displayed better self-confidence than the non-medalists as supported by Kuan and Roy (2007), Loehr (1986). Motivation helps players to achieve their best and enhance mental toughness (Connaughton et al., 2008; Mohammad et al., 2009). Goal setting determines successful performance Weinberg and Weigand (1993), Weinberg (2003). It was concluded that medalist badminton players showed better mental toughness attributes than the non-medalists
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